{"id":1730,"date":"2026-08-31T14:42:23","date_gmt":"2026-08-31T21:42:23","guid":{"rendered":"https:\/\/knightlab.ucsd.edu\/?p=1730"},"modified":"2026-08-31T14:44:31","modified_gmt":"2026-08-31T21:44:31","slug":"megascale-microbiome-analysis-with-dartunifrac","status":"publish","type":"post","link":"https:\/\/knightlab.ucsd.edu\/?p=1730","title":{"rendered":"Megascale Microbiome Analysis With DartUniFrac"},"content":{"rendered":"

[link to article]<\/span><\/a><\/h4>\n
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DartUniFrac rethinks UniFrac computation by connecting phylogeny-aware microbiome distances to weighted Jaccard similarity and using fast weighted MinHash sketching to make large-scale analysis practical.
\nThe method is implemented in Rust with CPU parallelization and GPU acceleration, enabling UniFrac-scale analyses across millions of samples and billions of taxa. This opens the door to routine microbiome meta-analysis, large-scale resampling, and phylogeny-aware comparisons at dataset sizes that were previously computationally out of reach.\u00a0Check the paper details and code below.<\/p>\n

Congratulations to Jianshu and co-authors!<\/p>\n

Paper: https:\/\/www.nature.com\/articles\/s41587-026-03260-8<\/a>
\nCode:\u00a0https:\/\/github.com\/jianshu93\/DartUniFrac<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

[link to article] DartUniFrac rethinks UniFrac computation by connecting phylogeny-aware microbiome distances to weighted Jaccard similarity and using fast weighted MinHash sketching to make large-scale analysis practical. The method is<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1730","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/posts\/1730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1730"}],"version-history":[{"count":2,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/posts\/1730\/revisions"}],"predecessor-version":[{"id":1739,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=\/wp\/v2\/posts\/1730\/revisions\/1739"}],"wp:attachment":[{"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/knightlab.ucsd.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}